Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression
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Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression
The vast majority of Foxp3 regulatory T cells (Treg) exhibits constitutive expression of CD25 (IL-2Rα), which allows the constitution of the high affinity IL-2Rαβγ receptor, ensuring efficient IL-2 binding by Treg. Maintenance of CD25 expression at Treg surface depends on both cell intrinsic factors and environmental stimuli such as IL-2 itself. Whether other factors can participate to maintena...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0113314